A Computational Framework with Simplified Tonotopicity and Homeostatic Plasticity for Tinnitus Generation and Its Management by Sound Therapy

An auditory perception without any external source is referred to as tinnitus. Tinnitus can be perceived in the ears or in the head. There are numerous methods for tinnitus management and sound therapy is one of the most effective techniques for tinnitus treatment. In order to investigate mechanisms of tinnitus generation and the clinical effects of sound therapy, we have proposed conceptual and computational models with plasticity using a neural oscillator and a neuronal network model. In the present paper, we propose a neuronal framework with simplified tonotopicity of the auditory system. In this framework an integrate-and-fire neuron model is employed and homeostatic plasticity is incorporated. The computer simulation results show that the present framework can demonstrate the generation of oscillation and its cessation by external input. Our simulations suggest that the present framework is promising as a modeling approach for the tinnitus generation and the effects of sound therapy on its management. Key-Words: tinnitus, sound therapy, neuronal framework, tonotopicity, homeostatic plasticity, oscillation, inhibition